Citalopram

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History

Citalopram was first synthesized in 1972 by scientists at the pharmaceutical company Lundbeck and was first marketed in 1989 in Denmark. It was first marketed in the US in 1998.[1] The patent expired in 2003, allowing other companies to legally produce generic versions. Lundbeck has released escitalopram and acquired a new patent for it. In the United States, Forest Labs manufactures and markets the drug.

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Brand names

Citalopram is sold under these brand-names:

  • Akarin (Denmark, Nycomed)
  • C Pram S (India)
  • Celapram (Australia,[2] New Zealand),
  • Celexa (U.S. and Canada, Forest Laboratories, Inc.)
  • Celica (Australia)[2]
  • Ciazil (Australia,[2] New Zealand)
  • Cilate (South Africa)
  • Cilift (South Africa)
  • Cimal (South America, by Roemmers and Recalcine)
  • Cipralex (South Africa)
  • Cipram (Turkey, Denmark, H. Lundbeck A/S)
  • Cipramil (Australia,[2] Brazil, Belgium, Finland, Germany, Netherlands, Iceland, Ireland, Israel, Norway, Sweden, United Kingdom, New Zealand, South Africa, Russia)
  • Cipraned, Cinapen (Greece)
  • Ciprapine (Ireland)
  • Ciprotan (Ireland)
  • Citabax, Citaxin (Poland)
  • Citalec (Slovakia, Czech Republic)
  • Citalex (Iran, Serbia)
  • Citalo (Australia,[2] Egypt)
  • Citalopram (USA, United Kingdom, New Zealand, Denmark, Finland, Germany, Spain, Sweden, Switzerland, Canada)
  • Citol (Russia)
  • Citox (Mexico)
  • Citrol (Europe and Australia)[2]
  • Citta (Brazil)
  • Dalsan (Eastern Europe)
  • Denyl (Brazil)
  • Elopram (Italy)
  • Estar (Pakistan)
  • Humorup (Argentina)
  • Humorap (Peru, Bolivia)
  • Oropram (Iceland, Actavis),
  • Opra (Russia)
  • Pram (Russia)
  • Pramcit (Pakistan)
  • Procimax (Brazil)
  • Recital (Israel, Thrima Inc. for Unipharm Ltd.)
  • Sepram (Finland)
  • Seropram (various European countries, including Czech Republic)
  • Szetalo (India)
  • Talam (Europe and Australia)[2]
  • Temperax (Chile, Peru, Argentina)
  • Vodelax (Turkey)
  • Zentius (South America, by Roemmers and Recalcine)
  • Zetalo (India)
  • Zylotex (Portugal)[3]

Medical uses

Citalopram HBr tablets in 20-mg (coral, marked 508) and 40-mg (white, marked 509), and a United States one-cent coin (size 19.05 mm/0.75 in)

Depression

In the National Institute for Health and Clinical Excellence ranking of 10 antidepressants for efficacy and cost-effectiveness[4] citalopram is fifth in effectiveness (after mirtazapine, escitalopram, venlafaxine, and sertraline) and fourth in cost-effectiveness. The ranking results were based on the meta-analysis by Andrea Cipriani.[5] In another analysis by Cipriani, citalopram was found to be more efficacious than paroxetine and reboxetine, and more acceptable than tricyclics, reboxetine, and venlafaxine, but less efficacious than escitalopram.[6]

Evidence for effectiveness of citalopram for treating depression in children is uncertain.[7][8]

Panic disorder

Citalopram is licensed in the UK and other European countries [9][10] for panic disorder, with or without agoraphobia. The dose is 10 mg/d for a week, increasing to 20–30 mg/d, with a maximum of 40 mg/d.[11]

Ideation

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Citalopram-20mg.png

Off-label

Citalopram is frequently used off-label to treat anxiety, panic disorder, dysthymia[12] premenstrual dysphoric disorder, body dysmorphic disorder and obsessive–compulsive disorder.[13]
  1. Benjamin Rawe and Paul May for Molecule of the Month. 2009 Citalopram: A new treatment for depression Page accessed 16 February 2015
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Pharmaceutical Benefits Scheme (PBS) - Citalopram". Australian Government. 
  3. "Citalopram". International. Drugs.com. 
  4. See p410 of "National Clinical Practice Guideline 90. Depression: The treatment and management of depression in adults, updated edition (2010).". National Institute for Health and Clinical Excellence (UK). 
  5. Cipriani, A.; Furukawa, T. A.; Salanti, G.; Geddes, J. R.; Higgins, J. P.; Churchill, R.; Watanabe, N.; Nakagawa, A.; Omori, I. M.; McGuire, H.; Tansella, M.; Barbui, C. (2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: A multiple-treatments meta-analysis". The Lancet. 373 (9665): 746–58. PMID 19185342. doi:10.1016/S0140-6736(09)60046-5. 
  6. Cipriani, A.; Purgato, M.; Furukawa, T. A.; Trespidi, C.; Imperadore, G.; Signoretti, A.; Churchill, R.; Watanabe, N.; Barbui, C. (2012). Cipriani, Andrea, ed. "Citalopram versus other anti-depressive agents for depression". The Cochrane Library. 7 (7): CD006534. PMC 4204633free to read. PMID 22786497. doi:10.1002/14651858.CD006534.pub2. 
  7. Cohen, D (2007). "Should the use of selective serotonin reuptake inhibitors in child and adolescent depression be banned?". Psychotherapy and psychosomatics. 76 (1): 5–14. PMID 17170559. doi:10.1159/000096360. 
  8. Carandang C, Jabbal R, Macbride A, Elbe D (November 2011). "A review of escitalopram and citalopram in child and adolescent depression". J Can Acad Child Adolesc Psychiatry. 20 (4): 315–24. PMC 3222577free to read. PMID 22114615. 
  9. Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych (Office for Registration of Medicinal Products, Medical Devices and Biocides) "Archived copy" (PDF). Archived from the original (PDF) on 5 November 2013. Retrieved 24 September 2013. 
  10. British National Folmulary http://www.bnf.org/bnf/go?bnf/current/33059.htm
  11. Perna G, Bertani A, Caldirola D, Smeraldi E, Bellodi L. A comparison of citalopram and paroxetine in the treatment of panic disorder: a randomized, single-blind study" Pharmacopsychiatry 2001; 34: 85–90
  12. Hellerstein, DJ; Batchelder, S; Miozzo, R; Kreditor, D; Hyler, S; Gangure, D; Clark, J (2004). "Citalopram in the treatment of dysthymic disorder". Int Clin Psychopharmacol. 19 (3): 143–8. PMID 15107656. doi:10.1097/00004850-200405000-00004. 
  13. Poore J. "Celexa (citalopram hydrobromide)". Crazy Meds.